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An old drug finds new purpose against retinal neovascularization - Dotemirates
5 month 6 day

An old drug finds new purpose against retinal neovascularization

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that the anti-malaria drug amodiaquine inhibits the apelin receptor protein, which helps drive the vascularization behind diabetic retinopathy, wet age-related macular degeneration (AMD) and other conditions. Because the drug has been approved to treat malaria for decades, it could move relatively quickly through the pipeline to help patients. The study was published in the journal PLOS ONE. "We have a receptor that has no relationship to the malarial bug— - it just happens that this compound interacts with the receptor and turns it off," says associate professor Layton Smith,...


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Health News

2 month 2 week

Apple Watch has new features to detect heart problems, monitor falls

This story is from Kaiser Health News. For more than a decade, the latest Apple products have been the annual must-have holiday gift for the tech-savvy. That raises the question: Is the newest Apple Watch on your list — either to give or receive — this year? At first glance, the watch appears to be an ideal present for Apple’s most familiar market: the hip early adopters. Its promotional website is full of svelte young people stretching into yoga poses, kickboxing and playing basketball. (MORE: 2 high blood pressure medications added to recall of heart drug) But when Apple unveiled...
2 month 2 week

Progress made toward global measles milestones

(HealthDay)—From 2000 to 2017, progress was made toward global measles control milestones, but the milestones set to be achieved by 2015 have not been met, according to research published in the Nov. 30 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. Alya Dabbagh, Ph.D., from the World Health Organization in Geneva, and colleagues report progress toward global measles control milestones and regional measles elimination goals during 2000 to 2017. The milestones set to be achieved by 2015 were increasing routine coverage with the first dose of measles-containing vaccine (MCV1) among children aged 1...
2 month 2 week

'Unfinished agenda' in preventing lead poisoning

Over the years, the Centers for Disease Control (CDC) and its partners have made major progress towards reducing lead exposure in the United States. But more work remains in preventing lead poisoning in US children and adults, according to a special supplement to the Journal of Public Health Management and Practice. While US population blood lead levels continue to decline, researchers, public health officials, and policymakers still face challenges in reaching national goals in the fight against lead , according to an introductory editorial by Adrienne S. Ettinger, ScD, MPH, Perri Z. Ruckart, MPH, and Timothy A. Dignam, Ph.D., MPH,...

2 month 2 week

Mean cumulative lifetime prevalence of eczema 9.9 percent

(HealthDay)—The mean cumulative lifetime prevalence of atopic eczema is 9.9 percent, according to a research letter published online Dec. 4 in the Annals of Internal Medicine. Katrina Abuabara, M.D., from the University of California in Los Angeles, and colleagues estimated the age-specific prevalence of active across the using data from 1994 to 2013 from the Health Improvement Network. They calculated the prevalence of active disease requiring a physician visit or prescription during each year of follow-up. The researchers found that the cumulative lifetime prevalence of atopic eczema was 9.9 percent among 8,604,333 persons aged 0 to 99 years, with the...
2 month 2 week

Study finds increased long-term mortality in pediatric firearm injury survivors

Children and adolescents who survive assault, including by firearm, have increased long?term mortality compared to those who survive unintentional, nonviolent trauma. That is the primary finding of a study reported in the Proceedings of the 2018 AEM Consensus Conference: Aligning the Pediatric Emergency Medicine Research Agenda to Reduce Health Outcome Gaps, to be published in the December 2018 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). The lead author of the study is Ashkon Shaahinfar, MD, MPH, attending physician and ultrasound director, Division of Emergency Medicine, at UCSF Benioff Children's Hospital Oakland...
2 month 2 week

High lead levels found in some spices purchased abroad

Investigations of lead poisoning cases in New York City (NYC) have found high levels of lead in certain spices purchased abroad, reports a study in the Journal of Public Health Management and Practice, part of a special supplement devoted to Lead Poisoning Prevention. The study by Paromita Hore, Ph.D., MPH, and colleagues at the NYC Department of Health and Mental Hygiene highlights the potential risks of lead exposure from "non-traditional" sources, even as US population blood levels continue to decline. "While lead-based paint and occupational lead hazards remain the primary sources of lead exposures among New York City's lead-poisoned children...