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An old drug finds new purpose against retinal neovascularization - Dotemirates
2 month 1 week

An old drug finds new purpose against retinal neovascularization

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that the anti-malaria drug amodiaquine inhibits the apelin receptor protein, which helps drive the vascularization behind diabetic retinopathy, wet age-related macular degeneration (AMD) and other conditions. Because the drug has been approved to treat malaria for decades, it could move relatively quickly through the pipeline to help patients. The study was published in the journal PLOS ONE. "We have a receptor that has no relationship to the malarial bug— - it just happens that this compound interacts with the receptor and turns it off," says associate professor Layton Smith,...


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Health News

1 hour 16 minute

Sugary supplement mannose could help fight cancer

A nutritional supplement may be able to slow the development of some cancers and enhance the effects of treatment, a study in mice suggests.Mice with pancreatic, lung or skin cancer were given mannose, a sugar also found in cranberries and other fruits.It significantly slowed the growth of their tumours, with no obvious side-effects, researchers found.However, patients are being told not to start supplementing with mannose because of the risk of side-effects.Scientists hope to test the supplement in people soon. Mannose, which can be bought in health food shops and is sometimes used to treat urinary tract infections, is thought to...
1 hour 59 minute

ED utilization up for pediatric mTBI after TBI legislation

(HealthDay)—Implementation of state youth traumatic brain injury (TBI) legislation correlated with an increase in pediatric emergency department utilization for youth sports- and recreation-related mild TBI (mTBI) evaluation, according to a study published in the November/December issue of the Journal of Head Trauma Rehabilitation. Bhavna Singichetti, M.P.H., from the Center for Injury Research and Policy in Columbus, Ohio, and colleagues conducted a retrospective analysis to examine the effect of state youth TBI on pediatric emergency department utilization for sports- and recreation-related mTBI. Data were included for 452,900 emergency department visits by children ages 5 to 18 years between 2006 and 2014....
2 hour 2 minute

Treating spinal pain with replacement discs made of 'engineered living tissue' moves closer to reality

For the first time, bioengineered spinal discs were successfully implanted and provided long-term function in the largest animal model ever evaluated for tissue-engineered disc replacement. A new Penn Medicine study published in Science Translational Medicine provides compelling translational evidence that the cells of patients suffering from neck and back pain could be used to build a new spinal disc in the lab to replace a deteriorated one. The study, which was performed using goats, was conducted by a multidisciplinary team in the University of Pennsylvania's Perelman School of Medicine, School of Engineering and Applied Science, and School of Veterinary Medicine....

2 hour 3 minute

Advancement in drug therapies may provide new treatment for Cutaneous leishmaniasis

Cutaneous leishmaniasis (CL) is a parasitic infection caused by Leishmania parasite. CL cases have increased dramatically in Syria and neighboring countries due to conflict-related displacement of Syrians. A study published in PLOS Neglected Tropical Diseases by Rana El Hajj at the American University of Beirut, Lebanon describes the development of a novel immunomodulatory analog that may be an effective treatment of CL. Currently used therapies against CL may lead to partial or complete cure. However, they associate with many limitations, including repetitive painful injections, lack of availability, expensive cost, and emergence of resistant strains. Furthermore, their efficacy remains hindered by...
2 hour 7 minute

Typically human: Babies recognize nested structures similar to our grammar

At a mere five months of age, babies seemingly have the ability to recognize very complex grammatical structures. That is what a research team headed by Professor Angela Friederici from the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) and Professor Jutta Mueller from the University of Osnabrück has now shown in a new study published in Science Advances. Human language follows certain regularities. For instance, a plural noun must be accompanied by a plural verb, as in the following : "The kids from the neighborhood are playing." As a result, relationships arise where information at the...
2 hour 22 minute

IBD disability index for self-report reliable, valid

(HealthDay)—The Inflammatory Bowel Disease Disability Index (IBD-DI) for self-report (IBD-DI-SR) is reliable and valid for measuring disability in inflammatory bowel disease (IBD), according to a study recently published online in the Journal of Gastroenterology and Hepatology. Emma Paulides, from the University of Otago in Christchurch, New Zealand, and colleagues recruited ambulatory IBD who completed the IBD-DI interview and self-report version. Participants were randomly assigned to first complete the clinical interview or self-report. The IBD-DI-SR was validated by calculating the correlation coefficient between the clinician-completed and self-reported version of the IBD-DI and Cronbach's α of internal consistency of the self-report. Data...