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Half of European clinical trials have not complied with EU rules on reporting results - Dotemirates
6 day 13 hour

Half of European clinical trials have not complied with EU rules on reporting results

Half of clinical trials on the EU register have not reported results, despite rules requiring results to be posted within 12 months of completion, finds a study published by The BMJ today. The findings show that, although compliance with EU rules has been poor overall, trials with commercial sponsors are substantially more likely to have posted results than trials with non-commercial sponsors, such as universities, hospitals, governments and charities. They also show that EU registry data commonly contain inconsistencies that might prevent even regulators assessing compliance. The results of are used by clinicians, patients, and policy makers to make informed...


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Health News

32 minute 40 second

Synthetic sandalwood found to prolong human hair growth

A team of researchers led by Ralf Paus of the University of Manchester has found that applying sandalwood to the scalp can prolong human hair growth. In their paper published in the journal Nature Communications, the group describes experiments they conducted with the synthetic material and human skin samples, and what they found. The research built on prior work by a team that had found that a receptor cell in skin called OR2AT4 was sensitive to chemicals in synthetic —sandalwood application stimulated growth of keratinocytes. Because skin healing and are closely related, the researchers wondered if applying synthetic sandalwood might...

Engineered cell therapy rejected for aggressive adult lymphoma on NHS in England

A cancer immunotherapy has been provisionally rejected as a treatment for some adults with an aggressive type of non-Hodgkin lymphoma on the NHS in England. will be reviewed by the National Institute for Health and Care Excellence (NICE) at the end of October. Tisagenlecleucel (Kymriah) is one of a new line of immune-boosting treatments called CAR T cell therapies, which involve taking a patient's own immune cells and modifying them in the lab. When the engineered cells are given back to the patient, they're primed to recognise and attack cancer cells. Kymriah has been trialled for patients with an aggressive...
38 minute 4 second

Inflammation critical for preventing heart attacks and strokes, study reveals

Inflammation, long considered a dangerous contributor to atherosclerosis, actually plays an important role in preventing heart attacks and strokes, new research from the University of Virginia School of Medicine reveals. The work also raises an important caution about a high-profile drug, canakinumab, being tested to treat , which is the narrowing of arteries due to plaque buildup on the artery walls. The drug would need to be prescribed only to a select group of patients, UVA's research suggests. Inflammation and Atherosclerosis In medicine, is often viewed as harmful, something best suppressed with drugs. Health care company Novartis, for example, has...

40 minute 39 second

I can't sleep. What drugs can I (safely) take?

If you're having trouble sleeping, medicines shouldn't be your first option. Exercise regularly, cut back on coffee (and other caffeinated drinks) after midday, eat less in the evening, ease up on "screen time" before, and in, bed, practise meditation and try to have a quiet, dark bedroom dedicated mostly to sleep. But what if you've tried everything and are still struggling with sleep? Many people will want to turn to a medicine for help. Navigating the various options for effectiveness, safety and the potential to become habit-forming can be difficult. Long-term regular use of medicines to promote sleep should be...
49 minute 57 second

A rare genetic disorder is the reason behind this girl's big beautiful eyes

Big eyes are generally described as a good think and a facial feature that enhance a person’s appearance. But in some cases these enchanting eyes may not be a genetic advantage. Two-year-old Mehlani Martinez was born with big pretty eyes, but this feature may just leave her blind in the future. The child suffers from a rare disorder called Axenfeld-Gieger syndrome which causes small or non-existent irises making it look like the eyes don’t have a coloured part. The hole at the center called the pupil may be misshapen and in some cases there may be two pupils. Children with...
1 hour 17 minute

3-D-printed tracheal splints used in groundbreaking pediatric surgery

Children's Healthcare of Atlanta has performed Georgia's first-ever procedure to place 3-D-printed tracheal splints in a pediatric patient. A cross-functional team of Children's surgeons used three custom-made splints, which biomedical engineers at the Georgia Institute of Technology helped create using an innovative and experimental 3-D-printing technology, to assist the breathing of a 7-month-old patient battling life-threatening airway obstruction. "We are so fortunate to work with a leading engineering school like Georgia Tech to find innovative, potentially life-saving treatment options for our patients," said Donna Hyland, president and CEO, Children's Healthcare of Atlanta. "This is a great example of how aligning...